Abstract
Malondialdehyde (MDA) and total antioxidant capacity (T-AOC) levels, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), glutathione transferase (GST) and xanthine oxidase (XOD) activities were analyzed in serum, livers and kidneys of pigs treated with graded doses of fluoride (as NaF). Ninety-six Duroc-Landrace-Yorkshire crossbred growing pigs (48 barrows and 48 gilts, respectively), with similar initial weight 24.14±1.12kg, were randomly assigned to four different treatments. These treatments containing the following added F: basal control; 50 mg/kg F; 100 mg/kg F and 150 mg/kg F were randomly assigned to four pens (three barrows and three gilts) each in a completely randomized design. The results showed pigs treated with 150 mg/kg F significantly decreased average daily gain (ADG) (p<0.05) and increased feed/gain ratio (F/G) (p<0.05) compared to the controls. In the groups treated with fluoride, the contents of MDA increased, T-AOC levels and the activities of SOD, GSH-PX, CAT, GST and XOD decreased, and most of which altered significantly (p<0.05). The study therefore indicated the mechanism of excess fluoride on the impairment of soft tissues involved in lipid peroxidation and decreased the activities of some enzymes associated with free radical metabolism. (Asian-Aust. J. Anim. Sci. 2005. Vol 18, No. 4 : 552-556)
Highlights
Fluorine (F), both essential and toxic, is a trace element for farm animals
There have been a number of studies on fluoride in laboratory animals, the mechanism of fluorosis has been reported by many scholars (Weber et al, 1969; Kragstrup et al, 1989; Maurer et al, 1990)
The supernatant obtained was further centrifuged at 12,000 g for 20 min at 4°C to obtain the postmitochondrial supernatant, which was used for the assays of total antioxidant capacity (T-AOC), superoxide dismutase (SOD), GSH-Px, xanthine oxidase (XOD), CAT and GST
Summary
Fluorine (F), both essential and toxic, is a trace element for farm animals. the essentiality of trace amounts of F has been demonstrated (Messer et al, 1972), we have to face is excessive fluoride, but not absent. In China, fluorosis of domestic animals in fluorine polluting areas has been reported over 15 provinces and regions in recent years. There have been a number of studies on fluoride in laboratory animals, the mechanism of fluorosis has been reported by many scholars (Weber et al, 1969; Kragstrup et al, 1989; Maurer et al, 1990). Generation of free radicals, lipid peroxidation, and altered antioxidant defense systems are considered to play an important role in the toxic effects of fluoride on soft tissues (Patel and Chinoy, 1998; Han et al, 2004). In this study we mainly assess the effects of fluorosis on lipid peroxidation and antioxidant systems in serum, livers and kidneys of growing/finishing pigs, so as to further research the mechanism of fluorosis injuring soft tissues in animals and humans
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