Abstract
One hundred and sixty day-old Hainan chicks were randomly allotted into eight pens to investigate the effect of different dietary concentrations of chromium (Cr) in the form of chromium chloride, and different dosages of florfenicol on humoral immune responses by determining antibody titers to Newcastle disease (ND) vaccines using the hemagglutination inhibition test. The results indicated that ND antibody titers were significantly higher in chicks receiving Cr at low (5 mg/kg feed) and middle (10 mg/kg feed) dose compared with the control (p 0.05), but the ND antibody titers were significantly decreased in chicks receiving 200 and 400 mg/kg feed of the drug (p<0.01). The ND antibody titers of group receiving 200 mg/kg feed of florfenicol plus 10 mg/kg Cr were slightly higher than that of the group receiving single florfenicol of 200 mg/kg although, no significant differences were observed between these two treatments. It is suggested that the humoral immune response impaired by florfenicol (200 mg/kg feed) could not be significantly reversed by Cr (10 mg/kg feed). (Asian-Aust. J. Anim. Sci. 2004. Vol 17, No. 3 : 366-370)
Highlights
Florfenicol is D-d-threo-3-fluoro-2-dichloroacetamide1- (4 methylsulfonyl-phenyl)-1- propanol, a chemosynthetic, structural analog of chloramphenicol with a broad spectrum and similar mechanism of action
Florfenicol does not have the p-nitro group that has been associated with irreversible aplastic anemia in man (Neu and Fu, 1980; Yunis, 1981; Skolimowski et al, 1983), and has shown greater in vitro activity against pathogenic bacteria than either of its structural analogs, thiamphenicol or chloramphenicol
Compared with control group ND though the ND antibody titers were a little higher in chicks antibody titers were significantly higher in chicks fed the receiving 10 mg/kg Cr (III) plus 200 mg/kg florfenicol than basal diets supplemented with 5 and 10 mg/kg Cr (III) those of chicks treated with a same dosage of florfenicol
Summary
Laboratory of Pharmacology and Physiology, College of Veterinary Medicine, Huazhong Agricultural University. ABSTRACT : One hundred and sixty day-old Hainan chicks were randomly allotted into eight pens to investigate the effect of different dietary concentrations of chromium (Cr) in the form of chromium chloride, and different dosages of florfenicol on humoral immune responses by determining antibody titers to Newcastle disease (ND) vaccines using the hemagglutination inhibition test. The results indicated that ND antibody titers were significantly higher in chicks receiving Cr at low (5 mg/kg feed) and middle (10 mg/kg feed) dose compared with the control (p0.05), but the ND antibody titers were significantly decreased in chicks receiving 200 and 400 mg/kg feed of the drug (p
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