Abstract
BackgroundFish oils, which contain omega-3 polyunsaturated fatty acids as the active ingredients, possess anti-inflammatory activities and may have therapeutic potential in diseases with an inflammatory etiology. Fish oil supplement has been advocated for treating psoriasis which is a chronic inflammatory dermatosis.ObjectiveWe aimed to investigate the effects of fish oil supplement on psoriasis.MethodsWe searched CENTRAL, Embase and MEDLINE on 24 January 2018 for randomized control trials (RCTs) on the effects of fish oil supplement in treating psoriasis. The Cochrane Collaboration’s tool was used to assess the risk of bias of included RCTs. We performed a random-effects model meta-analysis to obtain the pooled treatment effect estimates.ResultsWe included 13 RCTs with 625 participants. Three RCTs involving 337 participants provided usable data for meta-analysis. Fish oil supplement did not significantly reduce the severity of psoriasis when assessed by Psoriasis Area and Severity Index score (mean difference − 0.28; 95% confidence interval − 1.74 to 1.19).ConclusionThe current evidence does not support the use of fish oil supplement in treating psoriasis.
Highlights
Fish oils, which contain omega-3 polyunsaturated fatty acids as the active ingredients, possess antiinflammatory activities and may have therapeutic potential in diseases with an inflammatory etiology
Psoriasis is a chronic inflammatory dermatosis characterized by well-demarcated erythematous plaques with silvery scales [1, 2]
Some studies have suggested that supplementation with fish oil, which contains omega-3 polyunsaturated fatty acids (ω-3 PUFAs) including eicosapentaenoic acid (EPA) and
Summary
Fish oils, which contain omega-3 polyunsaturated fatty acids as the active ingredients, possess antiinflammatory activities and may have therapeutic potential in diseases with an inflammatory etiology. Fish oil supplement has been advocated for treating psoriasis which is a chronic inflammatory dermatosis. Psoriasis is a chronic inflammatory dermatosis characterized by well-demarcated erythematous plaques with silvery scales [1, 2]. The hallmark clinical feature is the cutaneous manifestation, psoriasis has increasingly been recognized as a systemic inflammatory disorder with comorbidities including arthritis [3], cardiometabolic disease [4], uveitis [5], and chronic kidney disease [6]. Some studies have suggested that supplementation with fish oil, which contains omega-3 polyunsaturated fatty acids (ω-3 PUFAs) including eicosapentaenoic acid (EPA) and
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