Abstract
The effects of filtrates from enterotoxinogenicEscherichia coli B609C on some functions of human granulocytes and monocytes have been studiedin vitro. A considerable increase in the nitroblue tetrazolium (NBT)-reduction was observed in granulocytes exposed for a short time (30 min) to subtoxic concentrations of the filtrate. The spontaneous and chemotactic motility of such cells was decreased, while the ability to ingest fluorescein-labelled yeast particles remained unchanged. A stimulation of the NBT-reduction was also observed in monocytes, but it was lower than that of granulocytes, and higher concentrations of the filtrates were needed. Contrary to the observation made for granulocytes, the spontaneous and chemotactic motility of monocytes increased after exposure to the active filtrates. The ingestion of yeast particles by monocytes was then increased as well. Heat-labile enterotoxin was at least partially responsible for the effects observed, since the stimulation was decreased by heat-inactivation of the filtrate or by neutralization with antiserum against enterotoxin.
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