Effects of fibroblast growth factor in diabetes mellitus

Abstract

Many studies have shown that fibroblast growth factor (FGF)1, FGF19, FGF21 and FGF23 were involved in glucose metabolism. FGF1 could lower blood glucose by suppression of hypothalamic pituitary adrenal axis, reducing the synthesis of acetyl coenzyme A, enhancing insulin sensitivity, and the central effect. FGF19 had the effect of increasing glycogen and protein synthesis and reducing gluconeogenesis. The antidiabetic mechanisms of FGF21 included promoting the secretion of insulin, increasing the sensitivity of insulin, enhancing glucose metabolism and inhibiting glucagon secretion. FGF23 was related to glucose metabolism, but the mechanism is unclear. Among them, the effects FGF1 are more significant. FGF family may become a new target for the treatment of diabetes mellitus. Key words: Fibroblast growth factor; Glucose metabolism; Diabetes mellitus