Abstract
We have studied the effects of several compounds isolated from fetal urine on the production of PGE 2 by amnion and chorion cells which were maintained in primary monolayer culture. We conclude that desoxycorticosterone and vanillylmandelic acid stimulate PGE 2 synthesis by amnion, but adrenaline and kallikrein increase the biosynthesis of PGE 2 by chorion. These data suggest that human fetal urine could play a major role in events of parturition.
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