Abstract
The concept of developmental origins of health and disease conveys the notion that the exposure to an unfavorable environment during pregnancy and lactation programs changes in fetal or neonatal metabolism, which in turn increases the risks of developing diseases in adult life. The evidence for fetal programming for metabolic diseases derives from a large number of epidemiological and animal observations. Several nutritional interventions and exposures during diverse phases of pregnancy and lactation in rodents and humans, respectively, are associated with fetal and neonatal programming for metabolic syndrome. In this chapter, we revisit epidemiological studies and experimental models providing evidence for the fetal programming associated with the development of metabolic diseases.
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