Effects of fetal breathing movements on umbilical venous blood flow in fetal lambs

Abstract

The effects of fetal breathing movements on the blood flow pattern in the common umbilical vein were studied in six chronically instrumented fetal lambs between 106 and 143 days gestation. Umbilical venous blood flow was measured with an electromagnetic flow transducer around the intra-abdominal common umbilical vein. Fetal breathing movements were recorded by means of an intratracheal catheter. During rapid irregular breathing movements instantaneous umbilical venous blood flow showed undulations with the frequency of the breathing movements. An inspiratory movement, characterized by a fall in tracheal pressure (mean ± S.D. = 5.3 ± 1.7 mmHg) was accompanied by a decrease in instantaneous umbilical venous blood flow (mean ± S.D. = 10.5 ± 2.8%). This decrease in umbilical blood flow during inspiration was accompanied by an increase in intra-abdominal pressure. A much greater decrease (mean ± S.D. = 40.6 ± 18.4%) in instantaneous umbilical venous blood flow occurred during deep inspiratory efforts (mean pressure drop ± S.D. = 15.5 ± 4.3 mmHg), accompanied by marked increases in intra-abdominal pressure. Isolated expiratory efforts resulted in an increase in both tracheal (mean ± S.D. = 6.3 ± 2.6 mmHg) and intra-abdominal pressure, while umbilical venous blood flow decreased (mean ± S.D. = 33.5 ± 21.3%). These observations show the great influence of fetal respiratory movements on the blood flow pattern in the common umbilical vein. The changes in instantaneous umbilical venous blood flow are possibly brought about by changes in intra-abdominal pressure.