Abstract
Ligularia fischeri herb can be used for the treatment of jaundice and hepatic failure. This study was conducted to identify antioxidant activity and anti‐hepatotoxicity effects of fermented aqueous extracts from the leaves of Ligularia fischeri (LA). The contents of total phenolic compounds and caffeoylquinic acid (CQA) of fermented LA (LAF) significantly increased, compared to those of LA. The ABTS and DPPH scavenging activities of LAF were significantly elevated. Male Sprague‐Dawley rats were used as a D‐galactosamine (D‐GalN) animal model. The activities of GGT, AST, ALT and LDH were diminished in D‐GalN‐exposed and LAF‐treated animal groups (D‐GalN/LAF) relative to those in D‐GalN‐alone‐treated groups (D‐GalN). The HDL‐cholesterol levels were enhanced in D‐GalN/LAF‐treated groups, whereas the levels of LDL‐cholesterol and triglyceride declined. In addition, the SOD activity of liver tissues increased in the D‐GalN/LAF‐treated groups, but their MDA contents were reduced in these groups. Histopathological observations revealed that there were apoptotic cells appeared and mild portal inflammation occurred in liver tissues of D‐GalN/LAF‐treated groups. These results demonstrate that LAF may improve plasma lipid profile and alleviate hepatic damage by D‐GalN.
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