Abstract
The effects of felbamate (F) on vigabatrin (V) pharmacokinetics were examined in 18 healthy volunteers. In this double-blind 2-way crossover study, subjects were administered V 1 gm q12h p.o. with F 1200mg or placebo (P) q12h p.o. for 8 days. Concentrations of the inactive R-(−) and active S-(+)-enantiomers of V were measured by GCMS, and AUC0-12 and Cmax values compared following F and P treatment.The pharmacokinetics of both enantiomers of V were similar during concurrent treatment with either F or P. Furthermore, coadministration of F and V was well tolerated by the volunteers.
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