Effects of feeding Ricinus communis seed meal on liver enzymes makers of albino rats (959.8)

Abstract

The effect of feeding seed meal on livers enzyme markers was evaluated using albino wister rats. Sixteen (16) male albino rats were randomly divided into 4 groups (1, 2, 3 and 4). Ricinus communis was incorporated into normal rat diet at 5%, 10% and 20% inclusion levels and fed to group 2, 3 and 4 rats respectively, while group 1 which served as control was fed with normal diet for 28 days. At the end of the feeding period, the level of the liver enzymes markers [(Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkalime Phosphate (ALP)] were determined using standard methods.The serum bilirubin (conjugated and total) were also determined. The entire mean liver enzymes makers the conjugated and total bilirubin significantly decreased when compared with the control. The AST significantly increased when the test groups were compared with the control. The ALP also significantly reduced when compared with the control. The conjugated bilirubin concentrations significantly decreased when compared with the control while the total bilirubin concentration significantly increased when the test groups were compared with the control. The result of the experiment suggests that Ricinus communis meal may possess some hepatoprotective property.