Abstract
Objective: The purpose of this study was to determine the effect of extra virgin olive oil (EVOO) and rice bran oil (RBO) on glycemic control and lipid profiles in patients with type-2 diabetes mellitus (T2DM).
 Methods: Ten patients with T2DM received 15 ml/day of EVOO or RBO. Levels of fasting blood glucose (FBG), postprandial blood glucose (PBG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and triglycerides (TGs) were measured. RBO or EVOO was administered for 4 consecutive weeks. During a 2-week interval, the treatment was not administered. After this washout period, a crossover design was implemented by exchanging EVOO supplementation with RBO supplementation and vice versa for 4 consecutive weeks.
 Results: Changes in levels of FBG, PBG, TC, LDL-C, and TGs were not significantly different in the two groups. However, significantly decreased the levels of HDL-C were observed in both groups.
 Conclusion: RBO and EVOO had no significant influence on levels of FBG or PBG.
Highlights
Diabetes mellitus (DM) is a major public-health problem worldwide
In 2015, the American Diabetes Association stated that DM is a “collection of symptoms caused by an increase in blood glucose levels due to impaired secretion and insulin resistance or the effects of both” [1]
Dietary analyses are shown in table 1 and show no significant difference in the intake of calories, carbohydrates, lipids or fiber before and after treatment
Summary
Diabetes mellitus (DM) is a major public-health problem worldwide. In 2015, the American Diabetes Association stated that DM is a “collection of symptoms caused by an increase in blood glucose levels due to impaired secretion and insulin resistance or the effects of both” [1]. The International Diabetes Federation estimated that, in 2016,>415 million people worldwide experienced DM. It is estimated that by 2040, population of approximately 642 million will have DM symptoms [2]. The pathophysiology of type-2 diabetes mellitus (T2DM) is insulin resistance. The latter occurs due to the inability of insulin to stimulate glucose absorption in its target cells (muscle, fat) despite hyperinsulinemia [3, 4]
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