Abstract
The experiment was designed to test effects of experimentally induced hyperlysinemia on maze learning ability in the mouse. Six% L-lysine was placed in the drinking water during gestation, and/or during nursing and/or during postweaning in a factorial combination. The young were tested at 40 days of age in a water-escape T maze. A week later all animals were retested for retention. Findings revealed that overloads of lysine resulted in temporary impairment, but permanent impairment occurred only if excess lysine was administered during gestation. Biochemical analysis revealed a sharp decrease in urea nitrogen in the urine, and a blood ammonia and lysine increase.
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