Abstract
We evaluated the effects of exogenous arginine vasopressin on electrocortical activity in the fetal lamb. Eight experiments were conducted on 5 chronically instrumented fetal lambs. Arginine vasopressin was infused at the rate of 1.56-2.27 mlU/min/kg estimated fetal weight for 30 min. Fetal electrocortical activity was obtained by 2 stainless steel screw electrodes implanted bilaterally on the fetal parietal skull. A significant increase was seen in the number of times that electrocortical activity switched from low voltage to high voltage and from high voltage to low voltage. The mean duration of the low voltage state was significantly decreased, while the duration of high voltage remained the same. The percentage of time that fetuses spent in the low voltage state was significantly decreased and in the high voltage state was significantly increased. In conclusion, exogenous AVP affects the regulation of fetal electrocortical activity, including the frequency of switching from one electrocortical activity to another.
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