Abstract
Effects of exercise training on type 2-diabetes: the role of Meteorin-like protein.
Highlights
Meteorin-like protein (Metrnl) controls insulin sensitivity by the peroxisome proliferator-activated receptor gamma (PPAR) pathway, acts as an insulin sensitizer and possibly a therapeutic target for insulin resistance.[11-13]
Another report argued that up-regulation in peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1), as an important regulator that induces mitochondrial biogenesis and increases Metrnl in muscle tissue
Insulin resistance induced by a High Fat Diets (HFD) was impaired in adipocyte-specific Metrnl knockout subjects; otherwise transgenic mice with an overexpressing Metrnl in adipocytes were protected from diet-induced insulin resistance
Summary
Metrnl controls insulin sensitivity by the peroxisome proliferator-activated receptor gamma (PPAR) pathway, acts as an insulin sensitizer and possibly a therapeutic target for insulin resistance.[11-13]. Metrnl plays important roles in neural regeneration, turning white adipose to brown and insulin sensitization.
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