Abstract
Studies show that the autonomic nervous system (ANS) has an important impact on health in general. In response to environmental demands, homeostatic processes are often compromised, therefore determining an increase in the sympathetic nervous system (SNS)’s functions and a decrease in the parasympathetic nervous system (PNS)’s functions. In modern societies, chronic stress associated with an unhealthy lifestyle contributes to ANS dysfunction. In this review, we provide a brief introduction to the ANS network, its connections to the HPA axis and its stress responses and give an overview of the critical implications of ANS in health and disease—focused specifically on the immune system, cardiovascular, oxidative stress and metabolic dysregulation. The hypothalamic–pituitary–adrenal axis (HPA), the SNS and more recently the PNS have been identified as regulating the immune system. The HPA axis and PNS have anti-inflammatory effects and the SNS has been shown to have both pro- and anti-inflammatory effects. The positive impact of physical exercise (PE) is well known and has been studied by many researchers, but its negative impact has been less studied. Depending on the type, duration and individual characteristics of the person doing the exercise (age, gender, disease status, etc.), PE can be considered a physiological stressor. The negative impact of PE seems to be connected with the oxidative stress induced by effort.
Highlights
The autonomic nervous system (ANS) has been identified as playing an important role in affecting general health
The recent scientific literature has been carefully analyzed in order to demonstrate the existence of a close relationship between physical training and antiinflammatory and antioxidant effects on the autonomic nervous system
We know a lot about the benefits of exercise, but lack information about the correct mode, type, length and frequency of exercise necessary to gain such benefits
Summary
The autonomic nervous system (ANS) has been identified as playing an important role in affecting general health. The oxidative stress caused by these types of physical training has an important influence on the ANS. We first provide a brief introduction to the ANS network and its connections to the hypothalamic–pituitary–adrenal axis. We give an overview of the critical implications of ANS in health and disease, focused on inflammation and oxidative stress. The methodological approach used for the present review is a systematic meta-analysis. The aim of this article is to try to demonstrate the benefits of physical exercise on oxidative stress and inflammation and to ensure the maintenance of a harmonious balance between the sympathetic and parasympathetic nervous systems.
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