Effects Of Exercise Training On High Molecular Weight Adiponectin In The Healthy Male Rat

Abstract

PURPOSE: The high-molecular weight (HMW) form of adiponectin has been reported to be the most active form of this hormone and low plasma HMW adiponectin levels have been found to be associated with insulin resistance..This study was intended to investigate the effects of exercise intensity on plasma HMW adiponectin concentrations. METHODS: Thirty-two male Wistar rats (age 8 wks, wt. 185±50 g) were randomly assigned to one of four groups as follows: high intensity (HI: 34m/min ∼%80-%85 VO2max), moderate intensity (MI: 28m/min ∼ %70-%75 VO2max), low intensity (LI: 20m/min ∼ %50-%55 VO2max), and sedentary control (SED) groups. All experimental groups performed 12 weeks of exercise consisting of treadmill running on a 0° slope for 1 hr/day, 5 days/week. Fasting levels of circulating HMW adiponectin, testosterone, insulin resistance index (HOMA-IR) were measured after the exercise program. Data were analyzed using one-way ANOVA while Pearson's correlations were performed to identify possible relationships among the assessed variables. RESULTS: HMW adiponectin plasma concentration increased significantly at HI and MI exercise training groups (p<0.05). Also, HMW adiponectin was inversely related to HOMA-IR (r = -0.37, p=0.003), insulin (r = -0.46, p=0.008) and testosterone (r = -0.38, p=0. 03). CONCLUSIONS: It concluded that exercise intensity appear to be important parameter to increase plasma HMW adiponectin level in healthy male rat.