Effects of exercise training on adipokines and glucose tolerance in non‐obese spontaneously type 2 diabetic torii rats

Abstract

The male Spontaneously Diabetic Torii (SDT) rats develop hyperglycemia spontaneously without obesity. The purpose of present study was to investigate the effect of exercise training in SDT rat. The male SDT rats (10 weeks old) were randomly divided into an exercise training group (SDT+Ex) and a sedentary group (SDT), while the Sprague Dawley (SD) rats were used as control groups (SD+Ex and SD). The SDT+Ex and SD+Ex rats were trained on a treadmill at speeds up to 15 m/min for 60 min, 5 times per week for 14 weeks. An oral glucose tolerance test with estimation of total area under the curve (AUC), HbA1c, insulin, adiponectin, leptin and adipose tissue mass were measured. The level of blood glucose in SDT+Ex was significantly lower than that in SDT at 16 – 24 weeks old. In additon, AUC, HbA1c and epididymal adipose tissue mass in SDT were significantly higher relative to SD although there was no difference among SDT+Ex, SD+Ex and SD. Furthermore, there was no significant difference between the all groups in insulin and leptin levels. Although the level of adiponectin was significantly lower in SDT and higher in SDT+Ex rat than in SD rat. These results indicate that exercise training attenuates hyperglycemia and the decrease of adiponectin in non‐obese type 2 diabetes. Supported by Grants‐in‐Aid for Science Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology.