Abstract
1970 This study examined changes in exercise performance and skeletal muscle (SM) structure and function in 6 patients with carcinoma (Ca) following a 12 wk training program, which began immediately after they had completed chemotherapy (CT). Prior to and after the program patients underwent i) graded exercise to exhaustion to determine peak oxygen consumption (VO2peak) and peak workload (WLpeak), ii) isometric and isokinetic tests of skeletal muscle (SM) function and iii) SM biopsies for light and electron microscopic analysis. Results were compared to those from a sedentary, age and gender matched control group (C) tested on initiation of the study. Before training, VO2peak (24.2 ± 2.4 vs. 33.0 ± 4.5 mlO2/kg/min; p<0.05) was lower in Ca compared to C. However, WLpeak (147 ± 21 vs. 185 ± 28 W; p=NS) was not different between groups. Peak torque generated by the quads corrected for lean thigh volume (44 ± 5 vs. 45 ± 5 Nm/l; p=NS) and total power (TP) in a 60 sec isometric endurance test (26 ± 4 vs. 41 ± 7 W/l; p=NS) were not different between groups. However TP tended to be lower in Ca (p=0.08). SM histology was not abnormal in either group. After training, Ca decreased resting heart rate (80 ± 4 vs. 72 ± 4 b/min; p=0.05) whereas VO2 peak (24.2 ± 2.6 vs. 28.4 ± 1.9 mlO2/kg/min and WLpeak (148 ± 23 vs. 191 ± 28 W; p<0.05) increased so that the differences between Ca and C were no longer apparent. TP tended to improve (26 ± 4 vs. 33 ± 4 W/l; p=0.08) in Ca after training. This study suggests that the exercise tolerance and SM function of patients with Ca are only mildly impaired. Furthermore these patients show significant physiological improvements following exercise training despite recent high doses of CT agents.
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