Abstract
Rainbow trout (Oncorhynchus mykiss) were kept on diets containing three different alpha-tocopherol levels (0, 10, and 1,000 mg/100 g diet) to investigate the effects of excess doses of alpha-tocopherol on the liver lipids and liver functions. Both the content of the lipids except alpha-tocopherol in the liver and the triglyceride ratio in total lipids were significantly increased by the diets containing 1,000 mg of alpha-tocopherol per 100 g of diet. Many lipid droplets, 5-20 microns in the diameter, were observed in the liver. The TBARS per milligrams of liver lipids was decreased by 1,000-mg doses of alpha-tocopherol. GOT and GPT activity in serum were in the normal range regardless of the dose of alpha-tocopherol. From these data, it is considered that excess alpha-tocopherol promotes lipid accumulation enough to form droplets in the liver tissue, although liver function is not impaired.
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