Abstract
Objectives:To investigate the effects of etibatide combined with emergency percutaneous coronary intervention (PCI) on blood perfusion and cardiac function in acute myocardial infarction (AMI) patients.Methods:This was a prospective, randomized, controlled study. From November 2015 to June 2019, 196 patients with ST-segment elevation myocardial infarction (STEMI) undergoing emergency PCI admitted to Baoding First Central Hospital were enrolled. The 196 STEMI patients were randomly divided into experimental group and control group. In the experimental group, STEMI patients were treated with emergency PCI + etibatide; while in the control group, only PCI was performed. Observation indexes included: general data, myocardial perfusion and cardiac function indexes and major adverse cardiac events (MACE).Results:There was no significant difference in general data between the two groups (P > 0.05). The rate of ST-segment resolution (STR) in the experimental group was better than that in the control group (P < 0.05). In myocardial contrast echocardiography (MCE), higher peak intensity (PI) and shorter time-to-peak (TP) were observed in the experimental group compared with the control group (P < 0.05). The platelet aggregation rate was compared between the two group at the time points of before PCI, after PCI and two hour after drug withdrawal, and there was no significant change in the platelet aggregation rate of the control group between different time points (before PCI, after PCI and two hour after drug withdrawal); while the platelet aggregation rate of the experimental group was significantly lower after PCI and two hour after drug withdrawal than that before PCI (P < 0.05), and an obviously decreased platelet aggregation rate was found in the experimental group(P < 0.05). After three months of follow-up, there was one case of MACE in the experimental group and 1 case of MACE in the control group, without any difference in the incidence of MACE between the two groups (P > 0.05).Conclusion:Etibatide combined with emergency PCI could improve myocardial reperfusion and cardiac function in patients with acute STEMI without increasing the incidence of MACE.
Highlights
Acute Myocardial Infarction (AMI) was considered as a serious threat to the life and health of human beings
As regards changes of myocardial enzymogram and electrocardiogram: There was no significant difference in peak values of Creatine kinase (CK), CK-MB and TnI between the two groups (P > 0.05)
There was no significant difference in the ratio of TIMI3 blood flow between the two groups (P > 0.05); after Myocardial contrast echocardiography (MCE), higher peak intensity (PI) and lower TP were observed in the experimental group compared with the control group (P < 0.05) (Table-II)
Summary
Acute Myocardial Infarction (AMI) was considered as a serious threat to the life and health of human beings. Pak J Med Sci January - February 2021 Vol 37 No 1 www.pjms.org.pk 185 recovery of effective myocardial reperfusion were important measures to reduce the mortality and improve the prognosis of AMI patients.[1]. It has been found that there was an increased risk of bleeding with the application of tirofiban, and patients were clinically treated with tirofiban in small dose.[2,3,4,5] With the development of another representative drug, etibatide, there was a doubt in the application of etibatide in continually maintaining good clinical outcomes without increasing the risk of bleeding, the effect of etibatide was still needed to be further studied.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
