Effects of ethylketocyclazocine on behaviors in mice using multi-dimensional behavioral analyses

Abstract

The effects of ethylketocyclazocine, a relatively selective kappa opioid agonist on the behaviors in mice were examined by using multi-dimensional behavioral analyses. Within 15 min after the measurements, ethylketocyclazocine (0.03, 0.1 and 0.3 mg/kg) dose-dependently decreased the linear locomotion, rearing, and grooming behaviors in mice. Fifteen to 30 min ethylketocyclazocine (0.3 mg/kg) decreased most of the behaviors in mice. The ethylketocyclazocine (0.3 mg/kg)-induced behavioral effects were antagonized by naloxone (1 and 2 mg/kg). These data suggest that the decreases in the linear locomotion, rearing and grooming behaviors are mediated via kappa opioid system.