Abstract
Abstract The effects of disodium ethylenediaminetetraacetate (EDTA) and sodium citrate upon glycolysis of human platelets were compared. "EDTA platelets" consumed more glucose and produced more lactic acid while "citrate platelets" incorporated radioactive phosphate into phosphonucleotides more effectively. These differences were not entirely pH dependent and the use of the magnesium or potassium salt of EDTA did not alter the patterns of glucose consumption or lactic acid production obtained with disodium EDTA. Curiously, the platelet count decreased faster in citrate platelet rich plasma than it did in EDTA platelet rich plasma. The relationship between the effects of EDTA and citrate upon platelet metabolism and platelet function are discussed.
Published Version
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