Abstract
Many epidemiological studies have shown an association between heavy drinking and high blood pressure. D'Alonzo and Pell (1) estimated that hypertension was two to three times more common among alcoholics than among controls. A greater incidence of hypertension among heavy drinkers has also been reported in the prospective epidemiological studies of Dyer et al. (2) and Klatsky et al. (3). Gyntelberg and Meyer (4) and Beevets (5) both suggested that heavy drinkers have higher blood pressure than do thbse who do not drink. Experimental studies investigating shortand long-term effects of ethanol on blood pressure have had contradictory results. With short-term administration of ethanol, Grollman (6) observed modest increases in diastolic and systolic pressure in nondrinkers, whereas no effect was observed by Stein et al. (7) and a decrease was shown by Conway (8). Webb and Degerli (9) found an increase in arterial blood pressure in anesthetized ogs given intravenous ethanol. Maines and Aldinger (10) reported hypotension as a consequence of myocardial depression in rats receiving long-term alcohol treatment. The present study was performed to investigate blood pressure changes in rats given ethanol solution as the only fluid. Spontaneously hypertensive rats and genetically related normotensive controls were used in an attempt to observe the effect of ethanol on the development of high blood pressure.
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