Abstract
Investigations of the effect of estrogenic substances on pregnancy have not led to uniform, well-defined results. Since all of the previous work has been carried on with crude preparations, the explanation of the differences may lie in the nature of the impurities. The isolation of the two crystalline estrogenic compounds, theelin and theelol, afforded us the opportunity of excluding the effects of extraneous substances. Brouha and Simonnet (1) in 1925 reported that extracts of liquor folliculi, administered to rats during late pregnancy, had no effect on the gestation. In contrast to this work, Parkes and Bellerby (2) in 1926 found that in the white mouse pregnancy could be interrupted and rapid return to oestrus be brought about by administration of oestrin. Small dosages were used (one to five mouse units), although during the later stages of pregnancy larger quantities were necessary in order to bring about abortion. Later (1930) Parkes (3) reported that oestrin alone, in doses as high as 380 M.U. did...
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