Effects of Estrogen Replacement Therapy on Uterine Size in Girls with Turner Syndrome

Abstract

Background: More than 95% of girls with Turner Syndrome (TS) will eventually experience premature ovarian insufficiency, and many will require early hormone replacement therapy (HRT) to initiate puberty, develop secondary sex characteristics, and optimize uterine size. However, limited data exist on the effects of estrogen replacement on achieving mature uterine size, which is important in improving obstetric and gynecologic care for this population. The objectives of the current study are to evaluate the effects of HRT on uterine size in girls with TS.