Abstract
The effects of estradiol and progesterone on binge eating in ovariectomized (OVX) female rats were determined. Sixty‐one OVX Sprague‐Dawley rats were used. All rats had continuous access to chow and water throughout this 4‐week study. Four groups were maintained on chow only and assigned into four different 4‐day cyclic hormone treatments: EC (n=9): Estradiol day2; PC (n=9): Progesterone day3; EPC (n=9): Estradiol day2, progesterone day3; OC (n=7): Oil vehicle day2 and day3. Three other groups were maintained on a binge eating schedule –intermittent access (1 h on Mon, Weds, Fri) to an optional dietary fat – and assigned into three hormone treatments: EF (n=9): Estradiol alone; PF (n=9): Progesterone alone; EPF (n=9): Estradiol and progesterone. (1) Estradiol alone or combined with progesterone attenuated daily food intake tonically, relative to OVX rats, and cyclically, i.e. intake on day 4 was lower than intake on day 2. However, (2) there was no cyclic effect of estradiol on food intake during the 1‐h binge period. In addition, binge intake didn't differ among E, EP, and P groups. (3) Estradiol alone or combined with progesterone restored body weight compared to OVX and progesterone alone. Conclusion: Estradiol attenuates total food intake but fails to attenuate fat binge intake in OVX rats. It also fails to demonstrate a cyclic inhibitory effect on fat binge intake. Progesterone has no direct effect on binge eating.
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