Abstract
The effects of growth factors to regulate the activity of aromatase, as well as the synthesis of aromatase cytochrome P-450 ( P-450 AROM) have been studied in human ovarian granulosa cells obtained from women undergoing oocyte retrieval. Insulin-like growth factor I (IGF-I) increased aromatase activity as well as the synthesis of P-450 AROM, in a concentration-dependent fashion. The levels of hybridizable mRNA species encoding cytochrome P-450 AROM were also increased with IGF-I treatment. By contrast, epidermal growth factor (EGF) had no effect on these parameters when added alone, but markedly inhibited the action of follicle-stimulating hormone (FSH) to stimulate aromatase activity, and the synthesis of cytochrome P-450 AROM as well as lts ability to increase the levels of mRNA encoding the enzyme. It is concluded that these growth factors have opposite effects on aromatase activity, and that these actions reflect, in part, changes in the synthesis of cytochrome P-450 AROM which in turn are the consequence of changes in the levels of mRNA encoding this enzyme.
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