Abstract
Introduction: Overweight currently has become a major global burden. Salmon is one of the major sources for fish oil to treat inflammatory related cardiovascular diseases. Yellow-stripe scad (YSS) on the other hand, is a local Malaysian fish which can be a good substitute for salmon; however, the therapeutic effects of YSS is still unclear. Objective: Therefore, this study compared the nutritional values EPA+DHA of YSS and salmon on body mass index (BMI), leptin and activation markers for both platelet and endothelial cell. Methods: Healthy overweight Malaysian adults (n=45), aged 21-55 years old, were recruited for 6-months cross-over trial study. They were randomised equally to receive eight weeks of either steamed whole YSS fish or salmon fillet, for three days per week, obtaining approximately 7000 mg EPA+DHA weekly. The diets were switched after an eight-week washout period. Baseline dietary fish intakes were similar in the two groups. Results: Significant differences observed in serum leptin for YSS-baseline group I and salmon-baseline group II (p 0.05). Significant decreased were also observed in serum vWF and VCAM-I in salmon/baseline group II (p 0.05). However, there was no significant differences between YSS and salmon (P>0.05) on time and treatment in all variable after 16 week, but there was a significant effect of treatment on sCD40L from YSS and vWF from salmon (p<0.05) Conclusion: Both YSS and salmon could harmonized EPA+DHA into leptin, platelet and endothelial phospholipid membrane to decreased platelet and endothelial cell activation markers which may contribute to the cardioprotective effect of EPA +DHA. Thus, the health benefits of YSS fish “ikan selar” and salmon on leptin and prothrombotic parameter on healthy overweight adults may be similar.
Highlights
Overweight currently has become a major global burden
There was no significant differences between Yellow-stripe scad (YSS) and salmon (P>0.05) on time and treatment in all variable after 16 week, but there was a significant effect of treatment on sCD40L from YSS and vWF from salmon (p
Overweight is a condition characterised by low-grade inflammation that promotes an elevated incidence of atherosclerosis and complex complication of the cardiovascular disease, which increases the risk of morbidity and mortality (Abdelaal, Roux, & Docherty, 2017)
Summary
Overweight currently has become a major global burden. Salmon is one of the major sources for fish oil to treat inflammatory related cardiovascular diseases. Objective: this study compared the nutritional values EPA+DHA of YSS and salmon on body mass index (BMI), leptin and activation markers for both platelet and endothelial cell. Methods: Healthy overweight Malaysian adults (n=45), aged 21-55 years old, were recruited for 6-months cross-over trial study. They were randomised to receive eight weeks of either steamed whole YSS fish or salmon fillet, for three days per week, obtaining approximately 7000 mg EPA+DHA weekly. Baseline dietary fish intakes were similar in the two groups Both YSS and Salmon elevated EPA+DHA level of leptin, platelet and endothelial cell phospholipid membrane (data not shown). Body mass index (BMI), serum leptin and biomarkers of platelet and endothelial cell activation (sCD40L, P-selectin, IL-1β, vWF and VCAM-1) were evaluated. Metabolic disorder is often partnered with excessive body fat such as hypertriglyceridemia, dyslipidemia, decreased high-density lipoprotein (HDL) and impaired fasting glucose
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