Effects of environmental and lifestyle exposure on urinary polycyclic aromatic hydrocarbon metabolites

Abstract

TPS 771: Diet and lifestyle, Exhibition Hall, Ground floor, August 26, 2019, 3:00 PM - 4:30 PM Background: Urinary polycyclic aromatic hydrocarbons (PAHs) metabolites which reflect internal level of PAH are commonly used to evaluate exposure-response relationship between PAH exposure and adverse health effects on multiple organ systems. However, potential association of environment PAH exposure and lifestyle to urinary PAH metabolites is unclear. Hence, in this study, we evaluated the effect of four common PAH sources, including cigarette smoking, cooking status, traffic exposure and diet, on the level of urinary monohydroxylated PAH metabolites (OH-PAHs) among residents of urban community in China. Methods: Urinary OH-PAHs were measured among 4092 participants from the Wuhan-Zhuhai cohort. Variables of lifestyle were collected using questionnaire by trained investigators. Linear mixed models were conducted to explore the association between PAH sources and urinary OH-PAHs. Standardized regression coefficients were used to assess the relative importance of PAH sources. Results: The levels of total urinary OH-PAHs (∑OH-PAHs), 1-, 2-hydroxynaphthalene and 2-hydroxyfluorene were significantly positively related to tobacco smoking (P<0.01). The concentrations of ∑OH-PAHs, 1-, 2-hydroxynaphthalene and 9-hydroxyfluorene were significantly positively correlated with dietary intake (P<0.05). Elevated levels of 9-hydroxyfluorene and 1-hydroxyphenanthrene were found among the participants with long traffic time exposure (P<0.05). And 1-hydroxypyrene (1-OHP) was significantly associated with self-cooking (P<0.05). Moreover, urinary total OH-PAHs and hydroxynaphthalene were primarily affected by cigarette smoking, poor ventilation and dietary intake. Poor ventilation in kitchen, traffic exposure and dietary intake contributed most to urinary total hydroxyfluorene and hydroxyphenanthrene. And the most important sources to urinary 1-OHP were self-cooking and traffic exposure. Conclusions: The relationship and contribution to the species of urinary OH-PAHs varied from diverse exposure sources. And secondary ventilation could eliminate PAHs effectively.