Abstract
It is aimed to compare whether there are differences in endoplasmic reticulum stress, liver function, insulin resistance, and vascular endothelial function in patients with nonalcoholic fatty liver disease (NAFLD) with and without type 2 diabetes mellitus (T2DM). Forty patients with NAFLD, 38 patients with NAFLD combined with T2DM, and 30 patients with normal liver tissue were selected. They were set as Group A, Group B and Group C respectively. The expression level of glucose-regulated protein 94 (GRP94) and biochemical indicators such as alanine aminotransferase (ALT), free fatty acids (FFA), triglycerides (TG), gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), fasting blood glucose (FBG), and fasting insulin (FINS) were measured. Also, the calculation of the homeostatic model assessment for insulin resistance (HOMA-IR) index was performed. The reactive hyperemia index (RHI) was detected to evaluate the vascular endothelial function of patients. The comparison between groups and multi-factor analysis of the influencing factors of RHI was conducted. Compared with Group C, the expressions in Group A and Group B were distinctly enhanced (P <0.05). Also, the expression of GRP94 protein in Group B was distinctly higher than that in Group A (P <0.05). The average optical density values of Groups A, B, and C were 0.327 ± 0.007, 0.350 ± 0.009, and 0.299 ± 0.006, respectively. A comparison between the three groups was performed. The differences had statistical significance (P <0.05). The differences in the TG, ALT, AST, GGT, FINS and HOMA-IR between Group A and Group B had statistical significance (P <0.05). The RHI values of Groups A, B, and C were 1.59 ± 0.23, 1.79 ± 0.32, and 2.05 ± 0.47, respectively. A comparison between the three groups was performed. The differences had statistical significance (P <0.05). FFA, ALT and FBG in patients with NAFLD are risk factors for endothelial dysfunction (P <0.05). The liver damage caused by NAFLD may be related to the expression of GRP94. FFA, ALT and FBG are risk factors for endothelial dysfunction in NAFLD patients.
Highlights
The incidence of NAFLD is closely related to Currently, with the adjustment of diet structure endoplasmic reticulum stress (ERS), liver function, and lifestyle, the incidence of nonalcoholic fatty liver insulin resistance (IR), and vascular endothelial disease (NAFLD) has been increasing
40 NAFLD patients diagnosed by history, clinical manifestations and auxiliary examinations at XXX Hospital (December 2017-December 2019) and 38 patients with NAFLD combined with type 2 diabetes mellitus (T2DM) were selected
Inclusion criteria: the diagnosis of NAFLD is based on the diagnostic criteria established by the Fatty Liver and Alcoholic Liver Diseases Group of the Hepatology Branch of the Chinese Medical Association; the diagnosis of T2DM complies with the diagnostic criteria for diabetes published by the World Health Organization; patients with perfect clinical data
Summary
The incidence of NAFLD is closely related to Currently, with the adjustment of diet structure endoplasmic reticulum stress (ERS), liver function, and lifestyle, the incidence of nonalcoholic fatty liver insulin resistance (IR), and vascular endothelial disease (NAFLD) has been increasing. Inclusion criteria: the diagnosis of NAFLD is based on the diagnostic criteria established by the Fatty Liver and Alcoholic Liver Diseases Group of the Hepatology Branch of the Chinese Medical Association; the diagnosis of T2DM complies with the diagnostic criteria for diabetes published by the World Health Organization; patients with perfect clinical data. Compared with Group C, the RHI values of patients in Groups A and B were distinctly reduced, and the difference had statistical significance (P
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
