Abstract
The effects of intracerebroventricular (i.c.v.) administration of endomorphins-1 and -2, endogenous μ-opioid receptor agonists, on the spontaneous alternation performance associated with spatial working memory were investigated in mice. Endomorphin-1 (10 and 17.5 μg) and endomorphin-2 (10 μg) produced a significant decrease in percent alternation without affecting total arm entries. β-Funaltrexamine (5 μg) almost completely reversed the endomorphin-1 (10 μg)- and endomorphin-2 (10 μg)-induced decrease in percent alternation, although neither naltrindole (4 ng) nor nor-binaltorphimine (4 μg) produced any significant effects on alternation performance. These results suggest that endomorphins impair spatial working memory through the mediation of μ-opioid receptors.
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