Abstract
The effects of varying dietery phosphate on absorption and excretion of calcium, magnesium and phosphate by intact and parathyroidectomized rats were determined. Since altering the dietary ratio of Ca/PO4 affects the serum levels of calcium which in turnregulates parathyroid function, the effects of endogenous parathyroid secretion on the metabolism of these elements were also examined. Lowering the dietary Ca/PO4 from 2.10 to 0.042 increased significantly the dry weights of the parathyroid glands. Regardless of thedietary level of phosphate or state of parathyroid activity, no significant differences in net intestinal absorption or renal excretion of calcium or phosphate were found between intact and parathyroidectomized rats, but magnesium absorption by parathyroidectomized rats tended to behigher at all levels of dietary phosphate. Only at the lowest dietary Ca/PO4 ratio, i.e., when the greatest endogenous parathyroid activity occurred, were there any differences in renal excretion between intact and p...
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