Abstract
The present study investigates the encapsulated propolis on blood glycemic control, lipid metabolism, and insulin resistance in type 2 diabetes mellitus (T2DM) rats. The animal characteristics and biological assays of body weight, fasting blood glucose (FBG), fasting serum insulin (FINS), insulin act index (IAI), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured and euglycemic hyperinsulinemic glucose clamp technique were used to determine these effects. Our findings show that oral administration of encapsulated propolis can significantly inhibit the increasing of FBG and TG in T2DM rats and can improve IAI and M value in euglycemic hyperinsulinemic clamp experiment. There was no significant effects on body weight, TC, HDL-C, and LDL-C in T2DM rats treated with encapsulated propolis. In conclusion, the results indicate that encapsulated propolis can control blood glucose, modulate lipid metabolism, and improve the insulin sensitivity in T2DM rats.
Highlights
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by an elevated blood glucose concentration that results from inadequate insulin action in insulinsensitive tissues and from abnormal insulin secretion
Our findings show that oral administration of encapsulated propolis can significantly inhibit the increasing of fasting blood glucose (FBG) and TG in type 2 diabetes mellitus (T2DM) rats and can improve insulin act index (IAI) and M value in euglycemic hyperinsulinemic clamp experiment
Three weeks after drug administration, the body weight of model control group increased significantly than normal control group contemporary (P < .05, P < .01), and body weight of encapsulated propolis treated groups increased at equal pace with model control group (P > .05); the body weight of T2DM rats treated with positive drug increased quicker than model control group, and had significant difference on 7th and 10th week of drug administration (P < .05)
Summary
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by an elevated blood glucose concentration that results from inadequate insulin action in insulinsensitive tissues and from abnormal insulin secretion. The number of people diagnosed with T2DM is increasing at an alarming rate. According to a widely accepted estimation, the number of diabetic patients (most of them with T2DM) can reach 366 million by the year 2030, promoted by a dramatic increase in the incidence of obesity and a sedentary lifestyle [3]. T2DM, especially its developing complications, carries a very poor prognosis and may lead to a dramatic decrease of life expectancy. Much interest has been focused on the development of alternative medicinal foods, which includes screening of natural bioactive compounds with the ability to improve glucose control and lower the risk of complications [4, 5]
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