Abstract
Chronic administration of emitine to rats in the usual human therapeutic doses produced muscular weakness and impaired neuromuscular transmission. Recovery occurred about three weeks after its withdrawal. Intravenous injection of emetine into anaesthetised rats and cats produced a neuromuscular block which was more pronounced on tetanus than on single twitches. The block was antagonised by neostigmine and potentiated by tubocurarine. Acetylcholine-induced contractions of the tibialis anterior muscle of the cat were diminished. Emetine inhibited indirectly elicited contractions of the isolated rat diaphragm without affecting the muscle twitches elicited by direct stimulation. It decreased contractions of the osolated toad rectus abdominis muscle to acetylcholine. The results are consistent with a tubocurarine-like action of emetine on neuromuscular transmission.
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