Abstract
AbstractRats received 196 food pellets per day under a fixed‐time 90‐sec schedule with both 5% (w/v) ethanol and water freely available. More than 80% of the total daily fluid consumption was the 5% ethanol solution. Disulfiram, and a new aldehyde dehydrogenase inhibitor, EMD 15,700, both markedly decreased 5% ethanol intake and slightly increased water intake. These effects lasted for several days. The schedule‐induced polydipsia model of ethanol consumption in rats appears to be sensitive to the effects of drugs that inhibit ethanol intake in man.
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