Abstract
Summary The hypotensive and antidipsogenic effects of eledoisin, physalaemin and some synthetic eledoisin- or physalaemin-like peptides were studied in conscious rats, respectively after intravenous or intracerebroventricular administration. The effects of the peptides were compared to the hypotensive or anti-dipsogenic activities of eledoisin considered equal to 100. Eledoisin and its C-terminal nonapeptide proved to be the most active antidipsogens. Conversely, physalaemin and physalaemin-like substances were poor inhibitors of water intake, but potently lowered arterial blood pressure. Apparently, there was no relationship between hypotensive and antidipsogenic effects of the substances tested.
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