Abstract
We evaluated the effects of electroconvulsive shock (ECS) on the expression of two genes encoding 70 kDa stress proteins, in the rat brain. The study was carried out by in situ hybridization using oligonucleotide probes specific for either the constitutively expressed hsc73, or the strictly inducible hsp70 gene. Rats were submitted to single or repeated (7 days, one session for each day) sessions of Electroconvulsive Shock. Animals were sacrificed at various time after treatment. ECS enhanced the basal expression of hsc73 in limbic areas, such as dentate gyrus, CA3, and median habenular nucleus. ECS induced hsp70 mRNA, which was not detectable in control animals, specifically in the Dentate Gyrus. The effect was present 2 h following treatment. Both single and repeated ECS were similarly effective. The finding likely reflects neuroadaptive local changes associated with a generalized seizure activity.
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