Abstract
Although several advances have occurred concerning the use of electroconvulsive therapy, little progress has been made in understanding the mechanisms underlying its therapeutic or side effects. Na +,K +-ATPase is an important enzyme of central nervous system, responsible for ionic gradient maintenance and consumption of approximately 40–50% of brain ATP. This work was performed in order to determine Na +,K +-ATPase activity after acute and chronic electroconvulsive shock. Results showed an inhibition of Na +,K +-ATPase activity in the hippocampus 48 h, 7, 30, 60 and 90 days after a single electroconvulsive shock. Chronic treatment diminished the enzyme activity in the hippocampus 7 and 30 days after electroconvulsive (ECS) sessions. Our findings demonstrated that Na +,K +-ATPase activity is altered by ECS.
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