Abstract
The effect of electrical stimulation within the hypothalamus on gastric acid secretion was studied in 43 cats under both acute and chronic conditions. In a study on 36 cats anesthetized with sodium pentobarbital, gastric acid secretion induced by the iv infusion of pentagastrin was increased during and/or 15 to 75 min after stimulation in the anterior hypothalamus in 13 of 31 cats tested, and in the midlateral hypothalamus in 2 of 11 cats tested; no changes in acid secretion were found during or after stimulation in the medial hypothalamus in 11 cats tested. Seven cats in which stimulation in the anterior hypothalamus increased acid secretion were allowed to recover and were later tested under chronic conditions. In three of these cats stimulation of the previously effective sites repeatedly produced an increase in basal acid secretion. Similar stimulation in four other cats was effective in some sessions and ineffective in others. During a behavioral test all these cats showed the following effects of stimulation: restlessness, meowing, and and attempting to escape. None ate during stimulation, although occasional licking was observed. Another experiment was carried out on seven cats with electrodes implanted in the midlateral hypothalamus (six cats) or in the anterior hypothalamus (one cat). In these cats electrical stimulation produced approaches toward food and eating in the satiated state, without meowing or attempting to escape during a behavioral test. Basal gastric secretion was not increased during stimulation of the “feeding” sites, applied when the animals were hungry. In one of these cats electrical stimulation of another site, located in the anterior hypothalamus, produced an increase in acid secretion; cating was not evoked by stimulation of this site during the behavioral test. The present results seem to suggest that the hypothalamic regions related to gastric acid secretion are not identical to those related to eating.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
