Effects of edible Terminalia catappa L. seed oil on physiological parameters of Mus musculus L mice

Abstract

Terminalia catappa L. (TC) trees are grown in many parts of the world including Vietnam, their seeds have high lipids content used as feed, and the yield of Terminalia catappa L. seed oil (TCO) is high. A survey on Mus musculus L mice was conducted, in addition to the diet they were also given TCO daily to evaluate its safety and effects. Results after 72 h of use with the highest oral dose of 21780 mg/kg of mice, all instinctive behaviors of mice were normal, the survival rate was 100%, when increasing the oral dose to the weight of mice, there was a tendency of slight downward tend. Continuously given daily dose of 5445 mg/kg of mice for 14 and 28 days, no abnormalities affecting instinctive behaviors were detected, the weight of mice fluctuated but not much, Mouse death rate is 0%. Analysis results of blood physiological parameters including RBC (Red Blood Cell), HGB (Hemoglobin), HCT (Hematocrit), WBC (White Blood Cell), LYM (Lymphocyte), NEU (Neutrophil), PLT (Platelet Count) values are within the standard limits of healthy mice. Some other findings when prolonging the intake of TCO, the mouse coat was thick, soft, and smooth compared to the short time of 72-h use, the concentration of ALT (alanine aminotransferase), AST (aspartate aminotransferase) decreased to the standard of healthy mice that can regulate liver enzymes to reduce liver damage. Creatinine levels related to kidney function are low, but when observing the microscopic liver and kidney tissue, no lesions or abnormalities are detected.