Abstract
Edaravone is a free radical scavenger that protects the adjacent cortex during cerebral infarction. We created a hemiparetic model of cerebral thrombosis from a photochemically induced infarction with the photosensitive dye, rose bengal, in rats. We examined the effects of edaravone on recovery in the model. A total of 36 adult Wistar rats were used. The right sensorimotor area was irradiated with green light with a wavelength of 533 nm (10 mm diameter), and the rose bengal was injected intravenously to create an infarction. The edaravone group was injected intraperitoneally with edaravone (3 mg/kg), and the control group was injected with saline. The recovery process of the hemiplegia was evaluated with the 7-step scale of Fenny. The infarcted areas were measured after fixation. The recovery of the paralysis in the edaravone-treated group was significantly earlier than that in the untreated group. Seven days later, both groups were mostly recovered and had scores of 7, and the infarction region was significantly smaller in the edaravone-treated group. Edaravone reduced the infarction area and promoted the functional recovery of hemiparesis from cerebral thrombosis in a rat model. These findings suggest that edaravone treatment would be effective in clinical patients recovering from cerebral infarction.
Highlights
The number of stroke patients has been increasing with the aging of the population
Katrak et al have reported that the prognoses of patients with cerebral infarctions were poor with less efficacy of rehabilitation compared to those with cerebral hemorrhages [1]
The free radical scavenger edaravone was approved in Japan in June 2001 for the treatment of cerebral infarctions [2]
Summary
The number of stroke patients has been increasing with the aging of the population. Among the causes of stroke, cerebral infarction is one of the most challenging diseases. Katrak et al have reported that the prognoses of patients with cerebral infarctions were poor with less efficacy of rehabilitation compared to those with cerebral hemorrhages [1]. The free radical scavenger edaravone was approved in Japan in June 2001 for the treatment of cerebral infarctions [2]. Edaravone is currently widely used in clinics in Japan [3]. Combination therapy with tissue plasminogen activator and edaravone has begun, and functional improvements have been reported [4] with functional recovery effects in patients with lacunar infarctions [3, 5,6,7]
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