Abstract
The use of antipsychotic drugs for pediatric psychiatric disorders has risen significantly over the last three decades, despite an absence of data documenting their long-term effects on brain development. We have used rats as a model system to show that early-life risperidone administration increases locomotor activity and locomotor responses to dopaminergic drugs during adulthood. The present study compared the effects of early-life risperidone to early-life aripiprazole administration on locomotor activity and locomotor responses to NMDA receptor blockade during adulthood.
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