Effects of Early Ulinastatin Injection Combined With Hyperbaric Oxygen on Myocardial Enzymes and Cognitive Function in Patients with Acute Moderate and Severe Carbon Monoxide Poisoning

Abstract

To observe the effect of early ulinastatin injection combined with hyperbaric oxygen on myocardial enzyme and cognitive function in patients with acute moderate and severe carbon monoxide poisoning. From May 2017~December 2020, 104 patients with acute carbon monoxide poisoning coma were divided into groups according to their treatment plan, 52 cases in the control group were treated with hyperbaric oxygen. Ulastatin group 52 cases were treated with early ulastatin injection combined with hyperbaric oxygen. The curative effect and incidence of delayed encephalopathy were counted, the average recovery time of the two groups was recorded, the changes of Hasegawa dementia scale score and Mini mental state examination score were compared between the two groups and the differences of blood gas index, myocardial enzyme index, and oxidative stress index and blood viscosity were detected. Ulinastatin group had higher efficacy than the control group (p<0.05). The blood oxygen partial pressure and superoxide dismutase increased in ulinastatin group and control group. The blood carbon dioxide partial pressure, creatine kinase, creatine kinase isoenzyme, aspartate aminotransferase, lactate dehydrogenase and malondialdehyde, catalase, lipid peroxide decreased. The oxygen partial pressure, superoxide dismutase of ulinastatin group after treatment was higher than that of control group, carbon dioxide partial pressure, myocardial enzyme index and malondialdehyde, catalase, lipid peroxide were lower than those of control group (p<0.05). The whole blood (high and low cut) viscosity and plasma viscosity of ulinastatin group and control group decreased, the Hasegawa dementia scale score and Mini mental state examination score increased and the blood viscosity of ulinastatin group was lower than that of control group after treatment and the Hasegawa dementia scale score and Mini mental state examination score were higher than that of control group (p<0.05).Average recovery time of ulinastatin group was shorter than that of control group and the incidence of delayed encephalopathy was lower than that of control group (p<0.05). Early ulinastatin injection combined with hyperbaric oxygen in the treatment of acute carbon monoxide poisoning coma can reduce oxidative stress injury, reduce myocardial enzyme expression and blood viscosity, improve blood gas index, promote patients to wake up and reduce the occurrence of delayed encephalopathy. It is worthy of clinical recommendation.