Effects of early prone positioning on oxygenation and safety on the porcine model with gastric aspiration

Abstract

Objective To explore the effects of early prone positioning on oxygenation and safety on the porcine model with gastric aspiration, so as to provide evidence for clinical nursing practice. Methods A total of 16 female miniature pigs were selected as experimental animals. Gastric aspiration model was created by ejecting 3 ml/kg gastric contents fluids. Pigs were immediately randomly assigned into either the supine position (SP) or prone position (PP) , and were monitored for up to 6 hours after aspiration for oxygenation index, static compliance (Cst) and dyanamic compliance (Cdyn) of respiratory system, heart rate (HR) and blood pressure (BP) . Results Oxygenation index of both groups decreased rapidly after aspiration. Oxygen index in PP group was higher than that in SP group 1 hour after aspiration. There was significant difference in the trend of oxygenation index with time between the two groups during the experimental observation period (P 0.05) . There was no significant difference in HR and BP between the two groups within 6 hours after aspiration (P>0.05) . Conclusions Early prone position (especially immediate prone position) could improve oxygenation, and cause no deterioration of hemodynamics, which is a safe treatment for patients with gastric aspiration. Key words: Animal experimentation; Gastric aspiration; Prone position; Oxygenation index; Safety