Abstract
Background: Parenteral Nutrition (PN) provided to the Very Low Birth Weighti¼VLBWi¼premature infants should be resulted in gradually development as of the other fetuses following the same gestational age. Even after providing the proven beneficial parenteral nutrition supplements, VLBW infants are often presents with the unfavorable results; the main reason behind it is the decision of the administration of parenteral nutrition, whether it is in early life or later days. Objective: The objective of this study is to explore the effect of early and late parenteral nutrition in the VLBW premature infants. In this study we hypothesize that early parenteral nutrition is associated with comparatively beneficial outcomes. Methods: The PubMed (PubMed Central), Medline, and Google Scholar databases were searched from 1993 to 2013. Methodological quality assessment was based on the PRISMA guidelines. Data analysis were conducted with RevMan 5.3 Results: Ten studies including thirteen trials met our inclusion criteria. The aggregate results of trials showed that early parenteral nutrition was well tolerated by VLBW preterm infants and there was significant reduction in sepsis (RR=0.82, 95% CI=0.69~0.98, P=0.03) Conclusion: Comparison made between the patients provided early and late parenteral nutrition, the development and reduction of clinical disease were significantly lower in the early parenteral nutrition group. The cost-effectiveness of these preparations, however, needs to be further explored. The poor qualities of studies call into a question and robustness of the analysis.
Highlights
Parenteral nutrition (PN) in very low birth weight (VLBW) premature neonates is one of the most important treatment regimes in the early life
The aggregate results of trials showed that early parenteral nutrition was well tolerated by VLBW preterm infants and there was significant reduction in sepsis (RR=0.82, 95% confidence interval (CI)=0.69~0.98, P=0.03)
Comparison made between the patients provided early and late parenteral nutrition, the development and reduction of clinical disease were significantly lower in the early parenteral nutrition group
Summary
Parenteral nutrition (PN) in VLBW premature neonates is one of the most important treatment regimes in the early life. Though it is proved as a lifesaving option, but still there are several opinions on its administration. We try to explore the effect of early and late administration of PN on the account of different clinical outcomes, such as sepsis, Broncho-Pulmonory Disease (BPD), Intraventricular Haemorrhage (IVH), Mortality, Patent Ductus Arteriosus (PDA), Necrotizing Entercolitis (NEC) and Retinopathy of Prematurity (ROP). Even after providing the proven beneficial parenteral nutrition supplements, VLBW infants are often presents with the unfavorable results; the main reason behind it is the decision of the administration of parenteral nutrition, whether it is in early life or later days
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