Effects of Dysglycemia and Dyslipidemia on the Severity of Airflow Limitation in Patients with Chronic Obstructive Pulmonary Disease

Abstract

To study the effect of dysglycemia and dyslipidemia on the severity of airflow limitation in patients with chronic obstructive pulmonary disease, 292 patients with moderate and higher chronic obstructive pulmonary disease were collected from a hospital during the period November 2018 to November 2019. They were divided into the dysglycemia group (n=119) and the non-dysglycemia group (n=173), the hyperlipemia group (n=106) and non-hyperlipemia group (n=186). Lung function index including the forced expiratory volume in 1 s, forced expiratory volume 1/forced vital capacity and the forced expiratory volume in 1 s predicted. The blood gas indices including the partial pressure of carbon dioxide in the artery, the arterial partial pressure of oxygen and dyspnea index modified by the British Medical Research Council. Results indicated that the values of forced expiratory volume, forced expiratory volume 1 % predicted and forced expiratory volume 1/forced vital capacity in chronic obstructive pulmonary disease patients with dysglycemia were significantly higher than those in patients without dysglycemia (p<0.05). The values of forced expiratory volume 1, forced expiratory volume 1 % predicted, and forced expiratory volume 1/forced vital capacity in patients with chronic obstructive pulmonary disease in hyperlipidemia group were significantly higher than those in the non-hyperlipidemia group (p<0.05). Compared to the group without dysglycemia, the value of partial pressure of carbon dioxide in the artery in chronic obstructive pulmonary disease patients with dysglycemia was significantly higher (p<0.05), and the partial pressure of oxygen value was significantly lower (p<0.05). The partial pressure of carbon dioxide in the artery value of chronic obstructive pulmonary disease patients with hyperlipidemia was significantly higher than that of the non-hyperlipidemia group (p<0.05) and the partial pressure of oxygen value was significantly lower (p<0.05). The dispnea index modified by the British medical research council of the dysglycemia group was significantly higher than that of the non-dysglycemia group (p<0.05) and the modified dispnea index of the hyperlipidemia group was significantly higher than that of the non-hyperlipidemia group (p<0.05). Diabetes or hyperlipidemia will aggravate the severity of airflow limitation in patients with chronic obstructive pulmonary disease and dysglycemia and/or dyslipidemia were the risk factors of chronic obstructive pulmonary disease.