Effects of dynamic glucose and insulin resistance of continuous positive airway pressure to OSAHS in patients with type 2 diabetes

Abstract

Objective To investigating the effects of dynamic glucose and insulin resistance of continuous positive airway pressure (CPAP) to the obstructive sleep apnea hypopnea syndrome (OSAHS) in patients with type 2 diabetes. Methods 77 patients meeting the inclusion and exclusion criteria were using computer generated random sequence method divided into two groups, the experimental group (routine hypoglycemic treatment + CPAP) and the control group (routine hypoglycemic treatment). Contrast before intervention and intervention for 3 days, 1 month, 3 months, 6 months, 12 month of fasting plasma glucose, insulin levels, 2 hours blood sugar after meal, glycosylated hemoglobin, insulin resistance index, the average daily average blood sugar, blood sugar, 24 h average blood sugar, blood sugar fluctuation in the day and night blood glucose fluctuation. Results In the control group, intervention after 3 days, 1 month, 3 months, 6 months, 12 months each time compared with before intervention, improved the above indicators had no statistical significance (P>0.05). In the experimental group, compared with before intervention, the index change had no statistical significance intervention after 3 days (P>0.05), fasting blood glucose, blood sugar mean ambulatory glucose excursions (MAGE) at night to improve was statistically significant intervention after 1 month (P<0.05), dynamic blood sugar, insulin resistance, such as improving had statistical significance intervention after 3 months, 6 months and 12 month (P<0.05). Compared with 1 month after the intervention, the improvement of average blood sugar and blood sugar fluctuation in the day after were statistically significant in the intervention after 3 months (P<0.05). The insulin resistance index, the average blood glucose within 24 h, the average blood glucose, blood sugar fluctuation in the day, night improved blood sugar fluctuation was statistically different in intervention after 6 months and 12 month (P<0.05). Conclusions CPAP intervention can significantly improve the dynamic blood sugar and insulin resistance in OSAHS patients with type 2 diabetes mellitus, and the longer it is, the more obvious curative effect it is. Key words: Continuous positive airway pressure; Obstructive sleep apnea hypopnea syndrome; Diabetes; Insulin resistance