Effects of Duration of Diabetes and Diabetes Therapy (Metformin) on Fbxw7 Levels in Iraqi Type II Diabetic Patients

Abstract

Background: This study concentrated on evaluation the FBXW7 levels and other markers in T2DM patients related to the duration of metformin monotherapy and duration of T2DM. Method: The current study includes 60 diabetic patients type II and30 control subjects. The groups of patients were subdivided in to two groups: (group I) (30) Newly diagnosed T2DM which also subdivided to two groups(> 1 year, and <1 year). Group II(30) T2DM (who were treated with metformin monotherapy) which also subdivided into two group (> 1 year and <1 year). In the present study FBXW7, FetuinA, pentraxin3, Nitric oxide and insulin were determined bythe enzyme linked immune sorbent assay (ELISA). Biochemical markers, fasting serum glucose, and lipide profile were determined through spectrophotometere technique in patients and control groups. Result: The levelsof glucose, HbA1c and IR significantly affected byincrease the duration of diseaseWhile each of fbxw7, pentraxin 3,NO, and fetuin A not influenced by increase duration of disease. There was nonsignificant effect of metformin therapy duration on levels of Fbxw7,fetuinA, pentraxin3 and lipid profile. While IR showed significant decrease when the duration of treatment increase. Conclusion: Fbxw7, fetuinA, pentraxin3 and NO arenot affected by long duration of therapy or by duration of disease while glucose, HbA1c, and IR are affected by increase duration of diseaseonly. Whereas insulin and IR are affected by both; duration of disease and therapy.