Abstract
An association between DTP vaccination and onset of seizures in 40 patients diagnosed with Dravet syndrome was investigated by retrospective analysis of medical and vaccination records at Heidelberg Hospital, Victoria, Australia.
Highlights
In this long-term, follow-up study of patients diagnosed with Dravet syndrome, the main factor associated with improvement of seizure prognosis is the prevention of occurrence of convulsive status epilepticus in childhood
Patients with mutations in SCN1A whose first seizure was a convulsion were separated into 2 groups, those whose first seizure occurred on the day of or day after vaccination (n=12), and those with seizure onset 2 days or more after vaccination (n=25) or before vaccination (n=3)
Researchers at Medical University Vienna, Austria, report the efficacy and safety of the ketogenic diet (KD) in treatment of epilepsy in a 3-year 6 month-old girl with diabetes type 1 followed for 15 months
Summary
In this long-term, follow-up study of patients diagnosed with Dravet syndrome, the main factor associated with improvement of seizure prognosis is the prevention of occurrence of convulsive status epilepticus in childhood. An association between DTP vaccination and onset of seizures in 40 patients diagnosed with Dravet syndrome was investigated by retrospective analysis of medical and vaccination records at Heidelberg Hospital, Victoria, Australia. Patients with mutations in SCN1A whose first seizure was a convulsion were separated into 2 groups, those whose first seizure occurred on the day of or day after vaccination (n=12) (the vaccination-proximate group), and those with seizure onset 2 days or more after vaccination (n=25) or before vaccination (n=3) (the vaccination-distant group).
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